Human Bioassay of Antimotion Sickness Drugs,

Abstract

Great individual differences in response to antimotion sickness drugs administered in usual doses were revealed. In one experiment (involving 11 subjects and 7 drugs) the single best therapeutic response implicated all seven drugs tested (three single drugs and four fixed-dose combinations). In terms of percentage of subjects demonstrating a substantial beneficial antimotion sickness drug effect, administration of a fixed-dose combination of promethazine hydrochloride and ephedrine sulfate (25 mg each) proved to be outstanding; this combination of homergic drugs clearly exhibited a suprasummation effect. A few tests were conducted using larger than usual doses and the results support previous findings that for a maximal beneficial effect in response to a single dose, individuals may vary both with regard to the choice of drug and the amount administered.

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Document Details

Document Type
Technical Report
Publication Date
Apr 02, 1975
Accession Number
ADA009799

Entities

People

  • Ashton Graybiel
  • Charles D. Wood
  • Gene F. Perkins
  • James Knepton
  • John P. Hoche

Organizations

  • Naval Aerospace Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Alcoholic Beverages
  • Antiemetics
  • Bioassay
  • Biomedical Research
  • Cannabis
  • Classification
  • Combinatorial Analysis
  • Drug Combinations
  • Drug Users
  • Environment
  • Intensity
  • Intervals
  • Motion Sickness
  • Plastic Explosives
  • Psychology
  • Side Effects

Fields of Study

  • Medicine

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Neuroscience
  • Psychometric Testing or Psychological Assessment.