Serum Zinc, Iron, and Copper Concentrations during Typhoid Fever in Man: Effect of Chloramphenicol Therapy
Abstract
In volunteers experimentally infected with Salmonellatyphi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies-in volunteers with typhoid fever treated with chloramphenicol, in a volunteer with typhoid fever receiving cefazolin and gentamicin, and in untreated rhesus monkeys infected with Salmonella typhimurium-provided evidence that the increase in serum iron concentration during the febrile phase was the result of chloramphenicol therapy, whereas the increase in serum zinc concentrations was a disease-related phenomenon. The importance of trace-metal monitoring during infectious disease and chemotherapy is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 12, 1974
- Accession Number
- ADA010062
Entities
People
- H. L. Dupont
- R. B. Hornick
- R. M. Kluge
- R. W. Wannemacher Jr.
- Robert S. Pekarek
Organizations
- United States Army Medical Research Institute of Infectious Diseases