Effects of Immunodepression on Antibody Binding Affinity.
Abstract
There is a progressive increase in antibody affinity with time after immunization. Agents (adjuvants) which increase the magnitude of the immune response favor selection for high affinity antibody synthesis. Agents such as antigenic competition, cyclophosphamide, 6-mercaptopurine and anti-lymphocyte antiserum which nonspecifically depress the magnitude of the immune response tend to make selection for high affinity antibody synthesis proceed more slowly.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1975
- Accession Number
- ADA010237
Entities
People
- Gregory W. Siskind
Organizations
- Weill Cornell Medicine