Monkeys as Hosts of Human Malaria and Other Pathogens.
Abstract
Alouatta villosa villosa was experimentally infected with trophozoite stages of Plasmodium falciparum. Five serial passages were made in intact hosts, with maximum parasitemias in excess of 35,000 per cmm, thus establishing a new model for investigation. A virulent strain of vivax malaria showed average maximum parasitemias of more than 100,000 per cmm in Aotus, at least two times greater than such values with New World strains. Twenty-six monkeys representing 8 species were biopsied for vivax exoerythrocytic (EE) stages. EE forms were found in 4 A. geoffroyi, 2 Saimiri, 4 Cebus and 1 Aotus, from 7 to 11 days after inoculation. Some of the best development was seen in Cebus, a host refractory to the blood stages, while several unusual forms were apparent in Saimiri at 10 days. An acquired Aotus-adapted brasilianum strain produced parasitemias of 500,000 per cmm in Panamanian monkeys.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1975
- Accession Number
- ADA010650
Entities
People
- David C. Baerg
- Richard N. Rossan