Gastric Secretory Response to Acute Isotonic Hypervolemia.
Abstract
The effects of acute isotonic extracellular fluid volume expansion were studied in conditioned, anesthetized dogs who underwent pyloric ligation and creation of an external gastric fistula. A hypervolemic state was produced with intravenous Ringer's lactate solution. The canine stomach responded as a 'third-kidney' by significantly increasing gastric juice volume (528 per cent) and gastric acid output (696 per cent). This occurred paradoxically in the presence of a lactate load and a metabolic alkalosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1974
- Accession Number
- ADA011450
Entities
People
- Arnold G. Coran
- Avram R. Kraft
- Clifford M. Herman
- Louise D. Homer
Organizations
- Naval Medical Research Center