Cellular Viability, Metabolism and Growth Kinetics During Hyperthermia in the Physiological Range.

Abstract

The objectives of the project are to: (1) Establish a dose response curve to hyperthermia between normal incubation temperature and 40.5C; (2) to investigate the mechanisms of thermal disruption of normal cellular activities and attempt to correlate temperature induced effects with changes in high energy nucleotide availability, or with the levels of other metabolic regulators; (3) to investigate the mechanisms of increased thermal stability in previously heat treated cell cultures. A brief outline of research findings is presented.

Document Details

Document Type
Technical Report
Publication Date
May 23, 1975
Accession Number
ADA011484

Entities

People

  • Joshua R. C. Brown

Organizations

  • University of Maryland

Tags

DTIC Thesaurus Topics

  • Availability
  • Chemical Kinetics
  • Chemistry
  • Culture Techniques
  • Dynamics
  • Energy
  • High Energy
  • Hyperthermia
  • Incubation
  • Kinetics
  • Metabolism
  • Nucleotides
  • Physics
  • Regulators
  • Thermal Stability
  • Viability

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