Cardiophysiological Studies with Stressed Animals.
Abstract
The report presents data that show trifluoro-chloromethane (F-11) is more toxic to cardiomyopathic hamsters than to random-bred hamsters, and that the toxicity is qualitatively different as well. It was also shown in another species that the arrhymic potential of F-11 is increased by hypoxia and the arrhythmias observed are not the result of hypoxia alone. The data from these animal studies are not directly applicable to humans. Genetic cardiomyopathy is not presented as a model of human heart disease or even human cardiomyopathy. The acute hypoxia induced in rabbits is not representative of the acute hypoxic state of the patient with diseases such as asthma or respiratory failure. These data show only that animals with depressed physiologic reserve were more sensitive to F-11 than normal animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1974
- Accession Number
- ADA011858
Entities
People
- George J. Taylor
- Robert T. Drew
Organizations
- Air Force Research Laboratory