Development of a Synthetic Polymer Burn Covering.

Abstract

Laboratory and preliminary in vivo (burned rat model) testing of a freeze-dried collagen/poly-caprolactone film laminate (FDC/PCL) and a freeze-dried poly-caprolactone foam/poly-caprolactone film laminate (PCL foam/film) as wound coverings have been completed. Porcine skin has also been evaluated in vivo. The laminates are flexible and, when moistened, become somewhat transparent permitting observation of the wound. Early adherence of both coverings to the wound was realized. The force required to remove the PCL foam/film laminate from a full thickness excision wound increased from 170 dynes/sq. cm. on the first day post graft to 1500 dynes/sq. cm. by the tenth day. The force required to remove FDC/PCL laminates remained constant, 220 dynes/sq. cm., over the ten day test period. Insensible water loss rates from animals grafted with the laminates were similar to that from animals with human cadaver skin grafts. Color illustrations reproduced in black and white.

Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1975
Accession Number
ADA011919

Entities

People

  • Arthur D. Schwope
  • Donald L. Wise

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Buildings And Structures
  • Caprolactones
  • Collagen
  • Coverings
  • Excision
  • Laminates
  • Observation
  • Polymers
  • Research Facilities
  • Skin Grafts
  • Synthetic Polymers
  • Thickness

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