Effects of Alpha0Methyltyrosine and 5-Fluorouracil on Astrocyte Density in the Rat Spinal Cord Dorsal Funiculi after Stab-would Lesion.

Abstract

Rats were lesioned by a stab wound in the mid-thoracic spinal cord. Chemotherapy with alpha methyl-tyrosine (AMT) followed shortly. This represented an attempt to reduce the concentration of noreprenephrine which causes hemorrhage and subsequent necrosis of cells of the central nervous system. This was followed by determining the extent of post-trauma gliosis (astrocyte density). The AMT treated cord has an average astrocyte density that is 11.1% greater than the control (lesion and no chemotherapy). However, this difference was not statistically significant.

Document Details

Document Type
Technical Report
Publication Date
Jan 30, 1975
Accession Number
ADA012357

Entities

People

  • John Norman Grim

Organizations

  • Northern Arizona University

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Astrocytes
  • Biological Sciences
  • Cells
  • Central Nervous System
  • Chemotherapy
  • Hemorrhage
  • Necrosis
  • Nervous System
  • Spinal Cord
  • Tyrosine

Fields of Study

  • Biology

Readers

  • Mathematics or Statistics
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).