Gamma-Aminobutyric Acid Uptake and Metabolism in 'Aplysia dactylomela'

Abstract

Selected ganglia of Aplysia dactylomela were found to possess a sodium dependent gamma-aminobutyric acid (GABA) uptake system. Tissue to medium ratios as high as 20:1 were calculated in the buccal ganglion after a 45-minute incubation in 6 Micromoles GABA. The metabolism of accumulated GABA was low with 90 percent of the radioactivity remaining as GABA after a 45-minute incubation and 20-minute washout period. The buccal ganglion displayed a sodium dependent, high affinity uptake system with a Km = 52 Micromoles. No net sodium dependent accumulation was found in the pedal ganglion. In the buccal ganglion, light microscope autoradiography indicated that the sites of GABA accumulation were predominantly extraneuronal.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1975
Accession Number
ADA012639

Entities

People

  • G. H. Zeman
  • P. R. Myers
  • T. K. Dalton

Organizations

  • Armed Forces Radiobiology Research Institute

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  • Air Platforms

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Cells
  • Cellular Structures
  • Chemistry
  • Cytoplasm
  • Glutamic Acid
  • Kinetics
  • Materials
  • Metabolism
  • Nerve Fibers
  • Nerves
  • Nervous System
  • Neuroglia
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  • Peripheral Nervous System
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