The Effect of Adrenergic Beta-Receptor Blockade on the Metabolic Response to Centrifugation Stress,
Abstract
The metabolic effects of three short exposures to radial acceleration were examined following administration of either a beta-blocking drug (oxprenolol), or a placebo, in a group of 24 male subjects. Associated emotional stress was assessed using a line-marker technique, and from changes in heart rate. On placebo, centrifugation significantly increased non-esterified fatty acids (NEFA) and glycerol levels, but had little effect on blood glucose or lactate levels. Oxprenolol effectively abolished the increase in NEFA, but had no effect on glycerol levels. The drug abolished the emotionally-induced tachycardia observed during control period preceding centrifugation, but only partially abolished the tachycardia produced by centrifugation. It is concluded that increased noradrenaline secretion is responsible for the observed metabolic effects of centrifugation, and that the centrifugation-induced tachycardia is not a purely beta response.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1975
- Accession Number
- ADA013426
Entities
People
- M. H. Harrison