Mechanisms of Amizyl (Benactyzine) and Diphacil Action on the Brain

Abstract

Proof is presented that amizyl and diphacil may only block the central choline receptors, but have an effect on the presynaptic reservoirs of mediators. Amizyl releases noradrenalin from the synaptic vesicles. Diphacil stabilizes the presynaptic reservoirs of catecholamines, nicotine releases noradrenalin and, apparently, dopamine from the presynaptic reservoirs. It is proposed that the basis of action of nicotine on the brain is release of catecholamines from their presynaptic reservoirs and that central n- cholinolytics prevent this action of nicotine.

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Document Details

Document Type
Technical Report
Publication Date
Mar 12, 1975
Accession Number
ADA014048

Entities

People

  • S. S. Krylov

Organizations

  • United States Army Foreign Science and Technology Center

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Amines
  • Amplitude
  • Animals
  • Atropine
  • Catecholamines
  • Cells
  • Central Nervous System
  • Dopamine
  • Excitation
  • Experimental Data
  • Laboratory Animals
  • Nervous System
  • Norepinephrine
  • Reservoirs
  • Synaptosomes

Readers

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  • Neuroscience