The Role of Cholinergic Transmission in the Respiratory Center,
Abstract
A number of tertiary cholinolytics, which were administered intravenously, induced continuous discharges of impulses in the phrenic nerve and cessation of inhalation. All of these substances induce apnea in identical doses. There is no correspondence between the effect and the strength of the cholinolytic activity of the substances. Other tertiary cholinolytics under the same conditions do not induce inspiratory apnea. Intravenous administration of nicotine (up to 100 mg/kg) does not induce essential disruptions of impulsation of the phrenic nerve. Arecoline (up to 3.0 mg/kg) induces reduction of rhythm, it disrupts the equilibrium of breathing movements, and it decreases the amplitude of the action potentials of the phrenic nerve (APPN). Severing of the vagus nerves, denervation of the sinocarotid zones, and severing of the brain stem in the quadrigeminal and pons area do not essentially change the effect of cholinolytics and cholinomimetics on the APPN.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 12, 1975
- Accession Number
- ADA014658
Entities
People
- B. A. Ger
Organizations
- United States Army Foreign Science and Technology Center