Effects of Trypanocidal Drugs on the Replication and Function of Kinetoplast (Mitochondrial) DNA in Trypanosomes
Abstract
The report summarizes investigations of various enzymes in host and trypanosomes, the effects of trypanocidal drugs on enzyme systems isolated from trypanosomes, and the structure and transcription ability of purified kinetoplast DNA. Primary results and conclusions are: (1) Little homology exists between C. fasciculata purified kinetoplast and nuclear DNA; (2) The trypanocidal drugs berenil, ethidium bromide, antrycide, and suramin inhibit E. coli DNA and RNA polymerases; (3) Suramin is a potent inhibitor of E. coli RNA polymerase; (4) Isolated mitochondria have RNA polymerase activity; (5) Action spectral evidence has conclusively demonstrated the presence of cytochrome o and cytochrome aa3 in T. mega, B. culicis and L. tarentolae.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1975
- Accession Number
- ADA015015
Entities
People
- George C. Hill
Organizations
- Colorado State University