Studies on the Antigenic Composition of Coxiella burneti.
Abstract
Antigens derived from Coxiella burneti Phase I and Phase II have been studied in vivo and in vitro. Guinea pig vaccinated with formalin killed organisms or cell walls derived from these organisms developed measurable levels of cell mediated immunity. The whole cell material has some toxic properties which can be measured in vivo and in vitro. Cell wall preparations have substantially decreased toxicity properties. This loss of toxicity does not appear to affect the immunogenecity of the cell wall material when administrated by the subcutaneous route. Preliminary studies on the intranasal route of immunization point to a decreased immunogenecity of the cell wall preparation.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1975
- Accession Number
- ADA015568
Entities
People
- David J. Hinrichs
Organizations
- Washington State University