Adjuvant Effects on Immune Responses to Biologic Agents.
Abstract
Experimental results indicate that in vivo immune responses are dependent upon cellular traffic through lymphatic tissues. Since -T-lymphocytes rapidly recirculated between blood and lymph, this cellular population was easily depleted by lymph drainage resulting in indefinite renal allograft survival in rats. Attempts to produce similar effects with pharmocologic agents demonstrated that heparin disrupted cellular traffic into nodes by preventing lymphocyte attachment to high endothelial venules. Intravenous pertussis vaccine caused a sustained lymphocytosis and impaired immune responses while local injection of this material produced cellular trapping in regional nodes and enhanced immunity. These results suggest that pharmacologic manipulation of lymphocyte traffic could be used to enhance or impair immune responses to biologic agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 18, 1975
- Accession Number
- ADA015588
Entities
People
- Norman D. Anderson
Organizations
- Johns Hopkins University