Mechanism of Adaptation of the Organism to High-Altitude Hypoxia and the Problem of Prophylaxis,
Abstract
The report presents the results of a study of the synthesis of DNA, RNA and protein in the nuclei and mitochondria of the heart during the adaptation to intermittent action of hypoxia. The adaptive value of mitochondrial biogenesis in hypoxia consists apparently in the following. The occurring oxygen deficiency lowers the formation of ATP in each mitochondrion. Accordingly, the formation of ATP per unit mass of tissue decreases as well. In response to this, there is activation in mitochondrial biogenesis, and the amount of these organelles per unit mass of tissue increases. Summing up, the functional disturbances which appear primarily as a result of ATP deficiency are abolished inspite of the persistent oxygen insufficiency and the decrease in the formation of ATP by each mitochondrion. Further development of the research concerned with studying the mechanism of adaptation to hypoxia and its prophylactic effects may apparently play its own role in the elaboration of methods of prophylaxis and treatment of heart and brain diseases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 11, 1975
- Accession Number
- ADA015887
Entities
People
- F. Z. Meyerson
Organizations
- US Army Medical Information and Intelligence Agency