Influence of Altered Gaseous Environments on Lung Metabolism.
Abstract
The findings from this investigation indicated that 24h in vivo exposure to hyperoxia (100% oxygen) did not alter lung lipid synthesis but did alter lactate production and pyruvate metabolism. In vitro perfusion of lungs for 1.5h showed that direct exposure of lung to altered carbon dioxide tension does not produce edema. Moreover, direct exposure to altered carbon dioxide tension did not alter lipid synthetic capacity. Both lactate and pyruvate metabolism was altered with hypocapnia, while hypercapnia affected only pyruvate metabolism. Twenty four hour hypoxia significantly altered lung cyclic nucleotide levels. These data indicate that altered gaseous environments significantly change certain aspects of lung cellular activity and that changes in lactate and pyruvate metabolites may serve as sensitive indicators to lung dosage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1975
- Accession Number
- ADA015914
Entities
People
- Rodney A. Rhoades
Organizations
- Pennsylvania State University