The Study of Intracellular Metabolic Effects of Hyperbaric Oxygenation on Tissues of Rat and Dog: The Use of Succinate and Other Metabolic Intermediates as Preventatives.
Abstract
Effects of high pressure oxygen (HPO) on CNS and pulmonary system were examined at the subcellular biochemical levels in rat and dog at 1, 1.5, 2, 3, 5, 7, 9, and 11 ATA O2. Biochemical studies were used to show the effects of (HPO) exposures. Comparison of relative efficacy of protective agents (succinate, GABA, glutamate, GSH, cysteine, TRIS, disulfiram LiCl) were compared in the same species and same pressures of HPO. The use of metabolic stimulus to energy production was observed on the CNS and heart.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 20, 1975
- Accession Number
- ADA015968
Entities
People
- Aaron P. Sanders
Organizations
- Duke University Hospital