Coagulation Changes of Hemorrhagic and Septic Shock in Baboons.
Abstract
There is a lack of agreement concerning the nature and physiologic significance of changes in the blood coagulation system during shock. Much of the uncertainty is based on the differences among the clinical and animal conditions in which these changes have been studied. The authors studied the coagulation responses to hemorrhagic and gram-negative septic shock. In order to avoid the splanchnic vascular response of the dog, with the possible resultant endotoxemia which could complicate the picture of hemorrhagic shock, the baboon was used as a subhuman primate model. The resemblance of the baboon blood coagulation system to that of man offered an additional advantage of the use of that species.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1970
- Accession Number
- ADA016044
Entities
Organizations
- Naval Medical Research Center