Analogs of Cordycepin and Adenine Arabinoside (Ara-A) as Potential Antimalarial Nucleosides.

Abstract

Research has been devoted to the synthesis of 3'-C-alkyl analogs of the nucleoside antibiotic cordycepin as potential antimalarial agents with enhanced lipophilicity, improved membrane transport properties, and resistance to inactivation by adenosine deaminase. In part, the work has also been concerned with the synthesis of ester and amide derivatives of ara-A 3',5'-cyclic phosphate, in which passive transport of the drug into cells in intended to be facilitated via increased lipophilicity. Twenty compounds, of which four were target compounds of the 3'-C-alkylcordycepin type, were submitted to WRAIR for antimalarial evaluation.

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1975
Accession Number
ADA016107

Entities

People

  • AndrĂ© Rosowsky
  • Edward J. Mosest

Tags

DTIC Thesaurus Topics

  • Adenine
  • Adenosine
  • Antimalarials
  • Membranes
  • Nucleosides
  • Resistance
  • Test And Evaluation
  • Transport Properties
  • Transport Ships

Fields of Study

  • Chemistry

Readers

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