Toxicological Evaluation of n-Hexyl Carborane, Carboranylmethylethyl Sulfide and Carboranylmethylpropyl Sulfide
Abstract
The relative toxicities of technical grade n-hexyl carborane (NHC), carboranylmethylethyl sulfide (CMES) and carboranylmethylpropyl sulfide (CMPS) were investigated using rats, guinea pigs, rabbits and dogs. Each compound produced primary irritation when applied to the intact and abraded skin of rabbits. Data indicated little acute toxic hazard would be expected from acute accidental ingestion. Acute vapor and aerosol inhalation exposures of animals resulted experimentally in no deleterious effect from the three compounds. Respiratory irritation with some minimal lung damage and transient eye effects occurred in dogs and rats as a result of repeated exposures to aerosols of NHC for 6 hours per day, 5 days per week for 6 weeks at concentrations of 77 and 245 mg/cu m. NHC and CMPS appeared to be nonmutagenic on the basis of microbial assays, while CMES appeared to be weakly mutagenic.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1975
- Accession Number
- ADA016152
Entities
People
- Conrad R. Pope
- Maurice H. Weeks
- Richard A. Angerhofer
Organizations
- United States Army Medical Command