Mechanism of Innate Resistant to Viral Encephalitis.
Abstract
Prevailing explanations for genetic resistance to lethal flaviviral encephalitis in mice hold that resistance gains phenotypic expression through nonimmunological virus-host interactions. Thus tissues from resistant mice are believed to be inherently less capable, or less willing, to support viral replication than tissues from resistant mice. In contrast, data indicate that expression of genetic resistance to a flavivirus does involve immunological mechanisms. Moreover, the authors have hypothesized that immunoreactivity may be central to the phenotypic expression of resistance, rather than playing a secondary role in host defenses. Genetic resistance to a human flavivirus (Banzi) has been studied in congenic mice. These mice are histocompatible, but differ markedly in their ability to survive parenteral challenge with Banzi virus. The results are summarized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1975
- Accession Number
- ADA016169
Entities
People
- Pravin N. Bhatt
- Robert O. Jacoby
Organizations
- Yale University