The Integration of Cellular and Humoral Responses to Protozoan Parasites.
Abstract
The immunological mechanisms acting against the infection of rats with Plasmodium berghei and of mice infected with Leishmania tropica have been studied. In addition a system of serotyping of leishmania strains, using their excreted factor (EF) and of growing amastigotes in culture have been developed. Spleen cells of rats during the acute stage of the infection with P.berghei vigorously incorporate radioactive thymidine immediately after they are transferred into culture. But when stimulated with nonspecific mitogens they are practically unresponsive. In contrast, spleen cells of rats recovered from the disease are effective in adoptive transfer of immunity against the infection. Leishmania tropica produces a transient cutaneous infection in C3H mice, similar to the lesion found in man. The dynamics of the disease and the possibilities of adoptive transfer of immunity and of delayed hypersensitivity have been studied.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1975
- Accession Number
- ADA016172
Entities
People
- Avivah Zuckerman
- Charles L. Greenblatt
- Dan T. Spira