Endocrine and Pulmonary Response to Hemorrhagic Shock.
Abstract
The roles of adrenal and pancreatic hormones in modulating the metabolic abnormalities which occur following hemorrhagic shock with resuscitation, have been studied using rhesus monkeys. Data are given on skeletal muscle glucose and amino acid metabolism, insulin sensitivity for the shock induced adrenal steroid and epinephrine response in conditioning the subsequent metabolic abnormalities. Data on the pancreatic hormones are still incomplete, but preliminary inspection suggests a similar failure of changes in these hormones to account for post-shock metabolic abnormalities. Endothelial cell (EC) damage has been identified as a major factor associated with acute respiratory failure. Studies of the mechanics of breathing indicate that the reductions in cardiac output which so frequently occur with positive and expiratory pressure (PEEP) may be secondary to left ventricular failure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1975
- Accession Number
- ADA016304
Entities
People
- Herbert B. Hechtman
- Richard H. Egdahl
Organizations
- Boston University