Histamine-Induced Hypotension Modified by H1 and H2 Antagonists.
Abstract
The hypotensive response of monkeys to exogenous histamine was measured when the histamine was given without antagonist, after chlorpheniramine (10 mg/kg) or mepyramine (10 mg/kg), and after these two antagonists in combination with burimamide (20 mg/kg). The dose of histamine needed to elicit a 50 percent maximal response was: without antagonist, 0.115 micrograms/kg; after chlorpheniramine, 13.5 micrograms/kg; after chlorpheniramine and burimamide, 23.5 micrograms/kg; after mepyramine, 23.0 micrograms/kg; and after mepyramine and burimamide, 55.0 micrograms/kg.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1975
- Accession Number
- ADA016800
Entities
People
- T. A. Strike
- T. F. Doyle
Organizations
- Armed Forces Radiobiology Research Institute