Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.

Abstract

Chlorpromazine (CPZ) protects rabbits against anticholinesterase poisoning, while cyclic adenosine 3',5'-monophosphate (cAMP) potentiates the toxicity of anticholinesterase compounds. Chlorpromazine is shown to be a noncompetitive inhibitor of cAMP activation of cAMP-dependent protein kinase (PK). The metabolic and pharmacological consequences of CPZ inhibition of PK and its possible relationship to protection against anticholinesterase agents are discussed.

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1975
Accession Number
ADA017131

Entities

People

  • Donald M. Maxwell

Tags

DTIC Thesaurus Topics

  • Adenosine
  • Chemical Compounds
  • Chlorpromazine
  • Cyclic Compounds
  • Enzyme Inhibitors
  • Heterocyclic Compounds
  • Inhibition
  • Inhibitors
  • Organic Compounds
  • Pharmacologic Actions
  • Pharmacological Mechanisms Of Action
  • Poisoning
  • Toxicity

Fields of Study

  • Chemistry

Readers

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