Increased 2,3-Diphosphoglycerate During Normocapnic Hypobaric Hypoxia,
Abstract
Maintenance of normal plasma pH at high altitude (HA) by acetazolamide has been shown to prevent the HA-induced change in 2,3-diphosphoglycerate (DPG) and P50. To establish whether this phenomenon occurs if hypocapnia is prevented, five subjects (Group I) and four subjects (Group II) were exposed to 440 torr with 3.7% CO2 supplemented and 455 torr with no CO2 supplemented for five days, respectively. Similar alveolar oxygen tensions were maintained in both groups. Group I P50s were significantly increased on days 2-5, while no changes were observed in Group II until day five. Both groups had significant elevations in DPG above sea-level values after two days. Mean corpuscular hemoglobin concentrations (MCHC) remained within normal limits during the first two days, then decreased significantly below sea-level values in Group I (days 3-5) and Group II (days 4-5). Thus prevention of respiratory alkalosis by CO2 supplementation is accompanied by increases in P50 and DPG; these changes occur independently of changes in MCHC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 05, 1975
- Accession Number
- ADA019513
Entities
People
- Allen Cymerman
- John T. Maher
- John T. Reeves
- Joseph C. Denniston
- Julio C. Cruz
Organizations
- United States Army Research Institute of Environmental Medicine