Synthesis of Organic Compounds for Malaria Chemotherapeutic Studies

Abstract

During the present report period, 40 compounds of the following categories have been synthesized, characterized, and submitted for antimalarial evaluation: (a) compounds having a triangular structural feature common to many causal prophylactic antimalarial agents; (b) alpha, beta-unsaturated amino acids and related derivatives; (c) compounds related to the antimalarial antibiotic furanomycin; and (d) deazafebrifugine and related compounds. 8-(6-Amino-3- hexylamino)-6-methoxy-4-methylquinoline diphosphate (WR-215761) exhibited outstanding antimalarial activity against P. berghei.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1975
Accession Number
ADA019554

Entities

People

  • C. C. Cheng
  • Ping-lu Chein
  • Shou-jen Yan
  • William H. Burton

Organizations

  • MRIGlobal

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Alkenes
  • Amino Acids
  • Chemical Synthesis
  • Chemistry
  • Hydrogen
  • Hydroxides
  • Organic Chemistry
  • Organic Compounds
  • Plastic Explosives

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.
  • Theoretical Analysis.