An Experimental Model for Chronic Communicating Hydrocephalus,
Abstract
A simple, relatively atraumatic and reliable technique is described for producing experimental chronic communicating hydrocephalus in dogs, cats, and primates by the subarachnoid injection of a room temperature curing silicone rubber in the anterior basal cisterns. Development of hydrocephalus is monitored by cisternography and by studies of radiopharmaceutical transfer from cerebrospinal fluid to blood. This model parallels closely the circumstances observed in the human disease. Its chronic time frame (1 to 10 months) allows meaningful examination of pathophysiological and neuroanatomical changes responsible for the observed human clinical signs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1975
- Accession Number
- ADA020976
Entities
People
- A. E. James Jr.
- B. L. Rish
- E. P. Strecker
- W. J. Flor
Organizations
- Armed Forces Radiobiology Research Institute