Propagation of Antibody Forming Cells in Diffusion Chambers.
Abstract
The magnitude of the secondary response to dinitrophenol (DNP), and the avidity of the antibodies produced, were studied in several inbred mouse strains. Both of these characteristics were found to be under genetic control. High responsiveness was inherited as a dominant trait. Several parameters of the secondary response to DNP were measured in young and old mice. It was found that the magnitude of the secondary response decreased with age, but the antigen dose response and the cytokinetics of the response were unchanged. The age-related decrease of immune potential was attributed to the development of large numbers of suppressor T cells in old mice. Induction of immunologic tolerance in B and T cells was studied in young and old mice. Old mice required 10 times more tolerogen that young mice for induction of B cell tolerance. There was no difference in the minimal tolerizing dose for T cells. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1976
- Accession Number
- ADA021169
Entities
People
- Diego Segre
Organizations
- University of Illinois Urbana–Champaign