Behavioral and Biochemical Effects of 4-Benzothienyl-N-Methylcarbamate (MOBAM, Trade Mark).
Abstract
Decreases in rat plasma, erythrocyte and brain cholinesterase levels after intraperitoneal injection of 1 to 5 mg/kg of 4-benzothienyl-N-methylcarbamate (MOBAM), were compared with decrements in spontaneous motor activity and changes in performance of a rapidly acquired conditioned avoidance response produced by this compound. Significant effects were observed with all five measures at dosages producing no obvious clinical signs. A dosage of 2 mg/kg significantly depressed plasma and erythrocyte cholinesterase activity and decreased motor activity 15 minutes after injection. Higher dosages (2.5 to 5 mg/kg) significantly depressed brain cholinesterase activity and avoidance performance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1975
- Accession Number
- ADA021681
Entities
People
- Perry J. Kurtz
Organizations
- United States Army Medical Command