Dopamine Depolarizing Response in a Vertebrate Neuronal Somatic Cell Hybrid.
Abstract
The response to iontophoretically applied dopamine was studied in the somatic cell hybrid 108CC15. Dopamine gave a depolarizing response with a conductance increase. The reversal potential for the response was -15.9 mV. Known dopamine antagonists blocked the response. These results demonstrate a dopamine response in a single cell preparation of vertebrate neuronal origin and the utilization of cultured cells to study receptor mechanisms in an isolated, controlled environment. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1975
- Accession Number
- ADA022072
Entities
People
- D. R. Livengood
- P. R. Myers
Organizations
- Armed Forces Radiobiology Research Institute