Sequential Immunization of Spider Monkeys with Three Group B Arboviruses: Yellow Fever, Langat, and Dengue-2.
Abstract
Spider monkeys were sequentially vaccinated with yellow fever, Langat and dengue type 2 attenuated viruses; three months later they and control monkeys which had been inoculated with the vaccine substrates but no virus were subcutaneously challenged with dengue type 4. Five vaccinated and 5 control monkeys were challenged with a small dose; 6 vaccinated and 5 control animals were given a large dose. As anticipated none of the animals developed signs of illness. No protection was observed against the large dose of dengue 4 virus. With the small challenge, there was a suggestion of protection at the borderline of statistical significance when the numbers of vaccinated and control animals developing viremia were compared; the difference between these two groups was highly significant when the total numbers of viremia-days were compared. In spite of the slightly favorable result observed with the spider monkeys given the small challenge dose of dengue 4 virus, it must be concluded at this time that, sequential immunization to achieve protection against a group B arbovirus not included in the vaccination has not been proved by our results to be an effective and practical measure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1975
- Accession Number
- ADA022832
Entities
People
- Jordi Casals-ariet
Organizations
- Yale University