Hyperemia and Edema in the Monkey Spinal Cord Following Injury: Modified by Histamine Antagonists.
Abstract
Using the hydrogen washout technique, blood flow in the lateral funiculus of the spinal cord of rhesus monkeys was measured before and after a contusion sufficient to render the animals paraplegic. In untreated animals, the blood flow increased 1 hour after injury to almost twice the normal flow rate (17.6 to 31.8 ml/min per 100 g). When the animals were pretreated with histamine antagonists (chlorpheniramine, an H sub 1 antagonist, and metiamide, an H sub 2 antagonist), there was no significant increase in blood flow following contusion. Antihistamines were ineffective in preventing edema. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1976
- Accession Number
- ADA024090
Entities
People
- A. I. Kobrine
- A. N. Martins
- T. F. Doyle
Organizations
- Armed Forces Radiobiology Research Institute