Effects of CNS Manipulations on Seizure Latency Following Monomethylhydrazine Administration in the Cat
Abstract
The objective of this study was to determine the influence of intracranial electrode placement upon the seizure response to monomethylhydrazine, and to replicate previous findings on the effects of EEG operant conditioning on this response. Thirty cats were studied, 10 in each of 3 different experimental groups. The dependent variable was latency in minutes to generalized motor seizures. The three experimental groups were: (1) an unoperated group, (2) an operated group with cortical and subcortical electrodes, and (3) an operated group as in (2), but provided additionally with sensorimotor rhythm (SMR) EEG operant conditioning. The findings suggested that (1) some aspect of the procedure associated with central nervous system electrode implantation increased susceptibility to MMH-induced seizures, (2) unoperated animals had individual differences in seizure susceptibility, but were significantly more resistant to MMH toxicity than operated animals, and (3) SMR-trained operated animals had individual differences in response to training, but were also more resistant to MMH toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1976
- Accession Number
- ADA024098
Entities
People
- M. B. Sterman
- M. D. Fairchild
- S. J. Goodman
Organizations
- UCLA David Geffen School of Medicine