Delineation of Immunogenic Regions by Tolerance Induction.
Abstract
Delineation of the portions of an anitgen which react with antibody is of importance in vaccine design and in combating allergic phenomena. These regions of a model antigen, oxidized ribonuclease, were mapped in a genetically pure line of mice (BALB/c) using a number of natural and synthetic fragments and a variety of immunological technics. Procedures for suppressing the immune response to oxidized ribonuclease were developed. Intact antigen or a peptide from the carboxyterminal region containing 20 amino acid residues given prior to or at the time of immunization suppressed the immune response. It is not clear whether the fragments suppressed antibody formation to only its own region or to the entire molecule.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1976
- Accession Number
- ADA024220
Entities
People
- Ray K. Brown
- Yi-chi M. Kong
Organizations
- Wayne State University