The Acute and Chronic Biochemical and Behavioral Effects of Cyclotrimethylenetrinitramine

Abstract

The overall objective of this project was to determine if trimethylenetrinitramine, a central excitatory agent, induces changes in behavior, in brain metabolism and in neurotransmitters. This objective was approached through a comparison of doses and time relationships between changes in biochemical parameters and changes in behavioral measures of brain activity. This report presents the results of studies designed to (1) Establish the effect of trimethylenetrinitramine on oxygen uptake and determine the effect on two specific brain enzyme systems, brain cholinesterase and monoamine oxidase. (2) Establish the effect of trimethylenetrinitramine on steady state levels and turnover rates of brain norepinephrine, dopamine, 5-hydroxytryptamine and possible gama-aminobutyric acid (GABA).

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 1975
Accession Number
ADA024415

Entities

Organizations

  • University of Maryland, Baltimore

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Biochemistry
  • Body Weight
  • Brain
  • Central Nervous System
  • Chemistry
  • Health Services
  • Human Behavior
  • Measurement
  • Movement Disorders
  • Nervous System
  • Pharmacology
  • Rdx
  • Seizures
  • Signs And Symptoms
  • Steady State
  • Time Intervals

Readers

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  • Neuroscience