Experimental Scrub Typhus Immunogens,
Abstract
This study arose from the conviction that an alternate method of rickettsial inactivation was requires. New data suggested that cell-mediated immunity (CMI), rather than antibody, was required for heterologous protection. Since the penetration of mammalian cells by rickettsiae requires active rickettsial metabolism, it was felt that radiation might be a tool that could be used to produce a non-replicating immunogen capable of infecting at the cellular level and possibly eliciting a cell-mediated immune response. Gamma radiation was chosen because it is more penetrating than ultraviolet radiation, thereby being more suitable for processing large volumes of immunogen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1976
- Accession Number
- ADA025995
Entities
People
- George H. G. Eisenberg Jr.
- Joseph V. Osterman
Organizations
- Walter Reed Army Institute of Research