First Successful Use of a Chemical Compound for the Prophylaxis and Treatment of a Lethal, Systemic, Viral Infection Common to Man and Subhuman Primates

Abstract

PIC-L is effective for the prophylaxis and early treatment of yellow fever virus infection of monkeys. Its importance is emphasized by the potentially overwhelming challenge dose used in the present studies. The demonstrated efficacy of this new interferon inducer should prove valuable for the control of other virus diseases caused by interferon-sensitive viruses for which no effective vaccines exist. PIC-L does not completely inhibit virus replication, and therefore possesses an important attribute of an ideal antiviral drug--it is not immunosuppressive.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1976
Accession Number
ADA026158

Entities

People

  • Edward L. Stephen

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Antiviral Agents
  • Chemical Compounds
  • Defense Mechanisms
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Inoculation
  • Interferon
  • Laboratory Animals
  • Proteins
  • Rhesus Monkeys
  • Virus Diseases
  • Viruses
  • Wound Infections
  • Yellow Fever

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Joint Military Operations and Doctrine.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology