Response of Combined Electrical Stimulation and Biodegradable Ceramic.
Abstract
This report presents a summary of the methods and results for 8 months of the first year investigation on the kinetics and tissue response of combining biodegradable porous ceramics and electrical stimulation for the correction of surgical defects in bone. Comparisons of healing characteristics of surgical lesions along rabbit tibias (5 control, 5 tricalcium phosphate and 5 tricalcium phosphate plus electrical stimulation) at 3, 6, and 12 weeks have shown considerable promise for this synthetic biomaterial and methodology. The animal model and evaluation techniques appear quite adequate for qualitatively and quantitatively evaluating the experimental conditions. Microscopy studies of the ceramic samples from the two sources showed differences in the microstructural dimensions of the porosity. Pore size distribution measurements showed the pore dimensions to extend from below 10 to above 600 micrometers with the average near 200 micrometers. The animal surgery and post operative follow-up proved routine after several specialty techniques were developed. Radiography and necropsy showed callus development associated with the synthetic biomaterial and most of the stabilization devices were removed after 6 weeks. Biomechanical strength tests showed similar magnitude strengths at each time period with a general increase in strength with time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 29, 1975
- Accession Number
- ADA027631
Entities
People
- J. E. Lemons
Organizations
- University of Alabama at Birmingham