Continued Development of an Implantable Sustained Release System for the Prevention of Malaria.
Abstract
The release of S(35)-labelled WR-7557 from three candidate polymeric matrices has been measured in vitro and in vivo in mice. They are 1/16 in. diameter beads and 1/32 in. diameter rods of a 50% d1-lactic/50% L(+)-lactic acid copolymer containg 33.3% WR-7557 and a 90 to 180 micron cryogenically ground powder of a 100% poly L(+)-lactic acid containing 20% WR-7557. The three materials released the drug very slowly, both in vitro and in vivo. A 90 to 180 micron powder has been ground from the 1/32 in. diameter rods to increase the surface area and in vitro and in vivo evaluation initiated. The release of WR-158122 has been measured from finely divided particles. Steady release of WR-158122 in vivo from a less than 44 micron spray dried powder of a 90% L(+)-lactic/10% glycolic acid copolymer containing 60% WR-158122 has been demonstrated with an extrapolated duration of release of over 500 days. The glycolate salt increased the solubility of WR-158122 significantly.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 19, 1976
- Accession Number
- ADA028254
Entities
People
- Donald L. Wise
- Lynne C. Anderson