Investigations Concerning the Pathogenesis and Therapy of Combined Injuries
Abstract
In preliminary tests, the question was investigated in how far the radiation lethality of test animals (NMRI mice) was modified not solely by open wounds but also by closed wounds (aseptic muscle necrosis), by the effects of heat and low temperatures as well as by a physical state of severe exhaustion (having forced them to swim). Although the influence of the individual types of stress being different, a trend was ascertained with combined injuries, demonstrating that the radiation lethality increased either not at all or just a little or even decreased significantly in the presence of simultaneously or prior to irradiation inflicted traumata, whereas traumata inflicted after irradiation mostly resulted in a high degree increase in radiation lethality. In subsequent tests the question concerning the causes for these changes in lethality were investigated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 06, 1974
- Accession Number
- ADA028735
Entities
People
- E. Joseph Metzger
- H. Sedlmeier
- O. Messerschmidt
- P. Schick
- R. Henneberg
Organizations
- US Army Medical Information and Intelligence Agency