Lesions in Guinea Pigs Infected with 'Coxiella burnetii', Strain M-44.
Abstract
Guinea pigs inoculated with the live, M-44 vaccine strain of Coxiella burnetii were examined grossly and microscopically for the presence of Q fever-related lesions. Mild myocarditis was observed in 38% of infected, but in none of the control animals. Livers showed significant incidence of hepatitis, necrosis and granuloma formation, especially during the first eight days of the infection. A much lower incidence of splenitis was also found but was considered to be of borderline significance. Generally, lesions were mild in nature and none seemed to endanger the life of the animal or cause observable distress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 18, 1976
- Accession Number
- ADA029448
Entities
People
- Carl E. Pedersen Jr.
- Charles G. Mcleod
- Glen A. Higbee
- James L. Stookey
- James W. Johnson
Organizations
- United States Army Medical Research Institute of Infectious Diseases