Behavioral and Biochemical Effects Of Malathion.
Abstract
Rat conditioned avoidance performance and spontaneous motor activity were examined after intraperitoneal injection with 25, 50, 100 or 150 mg/kg of the organophosphate insecticide, malathion. The effects of these dosages on plasma, erythrocyte, and brain cholinesterase activity were also assessed. Avoidance performance was significantly impaired 1 hour after injection with 50 mg/kg although blood and brain cholinesterase activity remained at greater than 90 percent of control values. The higher dosages (100 and 150 mg/kg) produced significant decreases in blood and brain cholinesterase activity as well as avoidance performance. Spontaneous motor activity was not significantly changed at any dosage. The results suggest that low dosages of malathion may disrupt behavior without significantly reducing cholinesterase activity. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 03, 1976
- Accession Number
- ADA030248
Entities
People
- Perry J. Kurtz
Organizations
- United States Army Medical Command