Reaction of Squirrel Monkeys to Intratracheal Inoculation with Influenza/A/New Jersey/76 (Swine) Virus

Abstract

To determine whether a model could be established for laboratory investigations, 9 squirrel monkeys were inoculated intratracheally with 10 to the 7th power EID 50 of influenza virus type A/New Jersey/8/76 (Hswl N1) (swine influenza virus). They responded with clinically detectable illness including fever, leukopenia, decreased food consumption, increased respiratory rate, occasional coughing, labored breathing, nasal discharge and lethargy. Convalescence was well advanced by the tenth day. All monkeys excreted virus for 7-8 days. A scoring procedure (illness score) has been developed for use in studies of vaccine and chemotherapeutic efficacy.

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Document Details

Document Type
Technical Report
Publication Date
Sep 29, 1976
Accession Number
ADA030474

Entities

People

  • Richard F. Berendt
  • William C. Hall

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Animals
  • Body Weight
  • Diseases And Disorders
  • Health Services
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Leukocytes
  • New Jersey
  • Respiration
  • Squirrel Monkeys
  • Standards
  • United States
  • Vaccines
  • Viruses

Fields of Study

  • Biology
  • Psychology

Readers

  • Infectious Disease/Epidemiology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology