A Continuous Aerosol Therapy System Utilizing a Modified Collision Nebulizer
Abstract
A Collision nebulizer was incorporated into an exposure system to administer antiviral compounds as continuous aerosols to mice infected by influenza virus. The nebulizer was modified to control aerosol output by varying the liquid feed-rate. A multiple regression equation was developed from data obtained with uranine dye to define the aerosol concentration in the system as a function of the concentration of the test solution and the rate at which it was aerosolized. The rate of change of the concentration of the test solution due to evaporative losses was also ascertained for a 1 ml/min feed-rate over a 23.5-period of operation. Procedures are outlined for using these relationships to determine the concentration of a solution that will result in a given dose. Performance data for the drug ribavirin are presented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 28, 1976
- Accession Number
- ADA030747
Entities
People
- Edgar W. Larson
- Harold W. Young
- Jerry S. Walker
- Joseph W. Dominik