Isolation of Renal Membranes That Contain Kalli-Krein, Angiotensin I-Converting Enzyme (Kininase II), and Angiotensinase.

Abstract

Fractions highly enriched in plasma membrane, endoplasmic reticulum, or brush border were prepared from rat kidney cortex. Kallikrein was concentrated in the plasma membrane fraction, but not in the brush border fraction. Angiotensin I-converting enzyme (kininase II) and angiotensinase were localized in the brush border membrane. It is suggested that kallikrein in the urine may originate from plasma membrane other than the brush border of proximal tubules and the conversion of angiotensin I and the inactivation of bradykinin and angiotensin II may occur on the lumen membrane of the proximal tubular cells. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Oct 15, 1976
Accession Number
ADA031453

Entities

People

  • Clark D. Gedney
  • Ervin G. Erodos
  • Patrick E. Ward
  • Robert M. Dowben
  • Rolland C. Reynolds

Organizations

  • University of Texas at Austin

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Angiotensin
  • Animal Structures
  • Biochemistry
  • Biological Factors
  • Biological Sciences
  • Blood Coagulation Factors
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Chemistry
  • Endoplasmic Reticulum
  • Enzymes
  • Internal Medicine
  • Kidneys
  • Membranes
  • New York
  • Proteins

Fields of Study

  • Biology

Readers

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  • Molecular and Cellular Biology
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