Immunity to Malaria Parasites.
Abstract
A standard procedure for the growth and multiplication of P. falciparum in human blood in microtissue culture trays is described. Out of over 100 Gambian and 80 Nigerian sera tested for their ability to inhibit reinvasion of P. falciparum in vitro, relatively few were strongly inhibitory. Some sera were inhibitory to parasites from some donors but not from others. The heterogeneous nature of the P. falciparum populations could account for this. It was found to be possible to circumvent this problem and relate immune sera to the specific population of P. falciparum against which they were raised by cryopreserving the parasite while the patient was treated and recovered from his infection. The individual and cooperative roles of T- and B-cells in immunity to P. chabaudi are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1976
- Accession Number
- ADA032794
Entities
People
- R. S. Phillips
Organizations
- University of Glasgow