The Thyroid Gland and Environmental Stress in Mammals.
Abstract
The affects of hyperoxia at ambient pressure on thyroid function and thyroid hormone metabolism have been assessed. Thyroidal activity, as indicated by the rate of uptake of I(125) by the thyroid, was depressed in mice by exposure to hyperoxia. Two methods were employed to assess the peripheral metabolism of thyroid hormone. The results obtained were dependent on the concentration of oxygen employed and/or the duration of exposure. Hyperoxia also resulted in a marked fall in circulating T4 concentration and a decrease in T4-binding activity in serum. These decreases in thyroid function and T4 metabolism were associated with a decrease in the rate of whole body oxygen consumption.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1976
- Accession Number
- ADA033098
Entities
People
- Valerie Anne Galton
Organizations
- Geisel School of Medicine